Thursday, February 02, 2006

Festa(r) & Festa(r) tagging SNPs

Yet another SNP tagging algorithm and program has been released, this time from the University of Michigan Center of Statistical Genetics.

Qin et al (2006) Bioinformatics 22:220-225 propose tagging on the basis of the pairwise LD measure r2 and have developed a fast and efficent algortihm which breaks genomic regions down into sections, allowing for faster computation of tagging SNPs has been developed to carry this out.

It avoids the potential drawback of multimarker approaches which may not perform well when genotyping fails.

This is a nice simple approach to increasing efficency, since there is little point in attempting to tag SNPs over long distances.


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